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KMID : 0383819680150030009
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Tuberculosis and Respiratory Diseases
1968 Volume.15 No. 3 p.9 ~ p.14
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CLINICAL STUDIES ON THE SIDE REACTION OF PYRAZINAMIDE
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함성숙(咸聖淑)/Sung Sook Ham
김경덕(金烱德)/Hyung Duk Kim
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Abstract
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Clinical research in the combined therapy of the secondary Anti·Tb. drugs, containing
Pyrazinamide, and its untoward side effects among the 39'1 active pulmonary Ib.
patients, chosen at random and who were previously on the primary drugs, was done
by the Chest Clinic at Severance Hospital of Yonsei University, from January 1963 to
December 1967.
The combination usally used wart pyrazinamide and ethionamide with nydrazid. And
the duration of using these drugs varied from two months to over one year.
Untoward reactions occurred in 54 patients (13.8%) out of 391, and generally two to
three months after the employment of pyrazinamide. Arthralgia was the most frequent
symptom in 44 patients(11.2%).
Hepatic damage, as evidenced by severe jaundice appeared in one patient about two
months after taking pyrazinamide, though it was reversible and subsided with the
discontinuance of the drug.
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KEYWORD
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